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Index > Protein center > SNAI2(Gene name) > Human
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  • SNAI2 (Gene name),
  • Zinc finger protein SNAI2 (Protein name ),  SNAI2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    SNAI2(SLUG;SLUGH);
    Protein name:
    Zinc finger protein SNAI2;
    Alternative:
    Protein snail homolog 2;Neural crest transcription factor Slug;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Transcriptional repressor. Involved in the generation and migration of neural crest cells.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    268
    Sequence:
    50:
    MPRSFLVKKH | FNASKKPNYS | ELDTHTVIIS | PYLYESYSMP | VIPQPEILSS | 
    100:
    GAYSPITVWT | TAAPFHAQLP | NGLSPLSGYS | SSLGRVSPPP | PSDTSSKDHS | 
    150:
    GSESPISDEE | ERLQSKLSDP | HAIEAEKFQC | NLCNKTYSTF | SGLAKHKQLH | 
    200:
    CDAQSRKSFS | CKYCDKEYVS | LGALKMHIRT | HTLPCVCKIC | GKAFSRPWLL | 
    250:
    QGHIRTHTGE | KPFSCPHCNR | AFADRSNLRA | HLQTHSDVKK | YQCKNCSKTF | 
    268:
    SRMSLLHKHE | ESGCCVAH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    MIM:
    UniGene:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Zinc finger protein SNAI2
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    E2412h
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    ELISA Kit for Human Zinc finger protein SNAI2
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    E2412b
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    96T
    ELISA Kit for Human Zinc finger protein SNAI2
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    E2412m
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    96T
    ELISA Kit for Human Zinc finger protein SNAI2
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    E2412r
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    CLIA Kit for Human Zinc finger protein SNAI2
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    U2412r
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    96T
    CLIA Kit for Human Zinc finger protein SNAI2
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    U2412b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Zinc finger protein SNAI2
    Cat.:
    U2412h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Zinc finger protein SNAI2
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    U2412m
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    Packing:
    96T
    Polyclonal Antibody for Human Zinc finger protein SNAI2
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    P2412Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Zinc finger protein SNAI2
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    P2412Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Zinc finger protein SNAI2
    Cat.:
    P2412Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Zinc finger protein SNAI2
    Monoclonal Antibody for Human Zinc finger protein SNAI2
    Monoclonal Antibody for Human Zinc finger protein SNAI2
    Monoclonal Antibody for Human Zinc finger protein SNAI2
    Monoclonal Antibody for Human Zinc finger protein SNAI2
    Protein for Human Zinc finger protein SNAI2
    Protein for Human Zinc finger protein SNAI2
    Protein for Human Zinc finger protein SNAI2
    Protein for Human Zinc finger protein SNAI2

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    References
    1. 1.
      "Human Slug is a repressor that localizes to sites of active transcription."
      Hemavathy K. , Guru S.C. , Harris J. , Chen J.D. , Ip Y.T.
      Mol. Cell. Biol.20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Melanocyte.
    2. 2.
      "Human SLUG gene organization, expression, and chromosome map location on 8q."
      Cohen M.E. , Yin M. , Paznekas W.A. , Schertzer M. , Wood S. , Jabs E.W.
      Genomics51:468-471(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region."
      Stegmann K. , Boecker J. , Kosan C. , Ermert A. , Kunz J. , Koch M.C.
      Mutat. Res.406:63-69(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-119
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Dermoid cancer.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    8. 8.
      "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
      Hajra K.M. , Chen D.Y. , Fearon E.R.
      Cancer Res.62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN WS2D
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PBT
    11. 11.
      "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells."
      Tripathi M.K. , Misra S. , Khedkar S.V. , Hamilton N. , Irvin-Wilson C. , Sharan C. , Sealy L. , Chaudhuri G.
      J. Biol. Chem.280:17163-17171(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
      Turner F.E. , Broad S. , Khanim F.L. , Jeanes A. , Talma S. , Hughes S. , Tselepis C. , Hotchin N.A.
      J. Biol. Chem.281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    14. 14.
      "Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors."
      Mingot J.M. , Vega S. , Maestro B. , Sanz J.M. , Nieto M.A.
      J. Cell Sci.122:1452-1460(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KPNA2; KPNB1; TNPO1 AND IPO7;MUTAGENESIS OF LYS-166; LYS-175; LYS-192; ARG-196; ARG-225 AND ARG-229
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    16. 16.
      "Functional regulation of Slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation."
      Kim J.Y. , Kim Y.M. , Yang C.H. , Cho S.K. , Lee J.W. , Cho M.
      FEBS J.279:2929-2939(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION;MUTAGENESIS OF SER-87; SER-92; SER-96; SER-100 AND SER-104
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